Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.

The Journal of biological chemistry - 23 Oct 2009

Toth Ann M, Li Zhiqun, Cattaneo Roberto, Samuel Charles E

Abstract excerpt

ADAR1 (adenosine deaminase acting on RNA) catalyzes the conversion of adenosine to inosine, a process known as A-to-I editing. Extensive A-to-I editing has been described in viral RNAs isolated from the brains of patients persistently infected with measles virus, although the precise role of ADAR during measles virus infection remains unknown. We generated human HeLa cells stably deficient in ADAR1 ("ADAR1(kd)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Adenosine Deaminase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to eIF-2 Kinase

Share to Inosine

Share to Interferon Regulatory Factor-3

Share to Measles

Share to Measles virus

Share to RNA, Double-Stranded

Source

Open in PubMed Open full text

Identifiers

PMID: 19710021
DOI: 10.1074/jbc.M109.045146
PMCID: PMC2785566

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.PMID 19710021Read ↗

Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein KinaseSemantic proximity Read ↗

Protein Kinase PKR Mediates the Apoptosis Induction and Growth Restriction Phenotypes of C Protein-Deficient Measles VirusSemantic proximity Read ↗

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150Semantic proximity Read ↗

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis.Semantic proximity Read ↗

The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus InfectionSemantic proximity Read ↗

Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKRSemantic proximity Read ↗

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophagesSemantic proximity Read ↗

Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the ApoptosomeSemantic proximity Read ↗

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cellsSemantic proximity Read ↗

Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.Semantic proximity Read ↗

Measles Virus C Protein Impairs Production of Defective Copyback Double-Stranded Viral RNA and Activation of Protein Kinase RSemantic proximity Read ↗

MAVS-Mediated Apoptosis and Its Inhibition by Viral ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.