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Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome

14 Sept 2017

Abstract excerpt

ABSTRACT Apoptosis is an important antiviral host defense mechanism. Here we report the identification of a novel apoptosis inhibitor encoded by the vaccinia virus (VACV)M1Lgene.M1Lis absent in the attenuated modified vaccinia virus Ankara (MVA) strain of VACV, a strain that stimulates apoptosis in several types of immune cells. M1 expression increased the viability of MVA-infected THP-1 and Jurkat cells and...

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Identifiers

PMID: 28904196
DOI: 10.1128/jvi.01385-17

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