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Article

Responsiveness to DDAVP in Cushing's disease is associated with USP8 mutations through enhancing AVPR1B promoter activity.

Pituitary - 1 Jun 2022

Shichi Hiroki, Fukuoka Hidenori, Kanzawa Maki, Yamamoto Masaaki, Yamamoto Naoki, Suzuki Masaki, Urai Shin, Matsumoto Ryusaku, Kanie Keitaro, Fujita Yasunori, Bando Hironori, Iguchi Genzo, Inoshita Naoko, Yamada Shozo, Takahashi Yutaka, Ogawa Wataru

Abstract excerpt

PURPOSE: To clarify the characteristics of Cushing's disease (CD) patients who respond to the desmopressin (DDAVP) test and its underlying mechanisms. METHODS: Forty-seven patients with CD who underwent DDAVP testing were included. Patients were divided into two groups: DDAVP test (+) (adrenocorticotropic hormone [ACTH] levels increased by ≥ 1.5-fold during the DDAVP test) and DDAVP test (-) (ACTH levels...

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PMID: 35451730
DOI: 10.1007/s11102-022-01220-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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