Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3',5'-monophosphate-responsive sequence in the bovine CYP17 gene.

doi:10.1210/mend.9.3.7776979

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Article

Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3',5'-monophosphate-responsive sequence in the bovine CYP17 gene.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 1995

Bakke M, Lund J

Abstract excerpt

ACTH-dependent transcriptional activation of the bovine CYP17 gene (the gene encoding cytochrome P450 steroid 17 alpha-hydroxylase) involves two cAMP-responsive sequences (CRS1 and CRS2) located in the promoter region. Here we demonstrate that two nuclear orphan receptors, chicken ovalbumin upstream promoter transcription factor (COUP-TF) and steroidogenic factor-1 (SF-1), bind to the part of the CRS2 element...

Topics

Animals
Base Sequence
COUP Transcription Factor I
Cattle
Cell Line
Cyclic AMP
DNA
DNA-Binding Proteins
Enzyme Activation
Fushi Tarazu Transcription Factors
Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Molecular Sequence Data

Mutation

Promoter Regions, Genetic

Protein Biosynthesis

Protein Kinases

Source

Open in PubMed

Identifiers

PMID: 7776979
DOI: 10.1210/mend.9.3.7776979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7776979-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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