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Article

Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype.

Cardiovascular research - 1 Feb 2003

Du Xiao-Jun, Samuel Chrishan S, Gao Xiao-Ming, Zhao Ling, Parry Laura J, Tregear Geoffrey W

Abstract excerpt

OBJECTIVE: To investigate cardiac phenotypes in mice deficient in the peptide hormone relaxin by gene targeting. METHODS: Echocardiography and cardiac catheterization were performed on male and female relaxin deficient (Rlx(-/-)) mice as well as heterozygous (Rlx(+/-)) and wildtype (Rlx(+/+)) littermates aged between 8 and 24 months. Collagen expression and content in the heart were analysed by real-time PCR,...

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Source

Identifiers

PMID: 12566112
DOI: 10.1016/s0008-6363(02)00663-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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