Article
Dual roles of proteasome in the metabolism of presenilin 1.
Journal of neurochemistry - 1 Jan 1999
Honda T, Yasutake K, Nihonmatsu N, Mercken M, Takahashi H, Murayama O, Murayama M, Sato K, Omori A, Tsubuki S, Saido T C, Takashima A
Abstract excerpt
Presenilin 1 (PS1) has been identified as a causative gene for most early-onset familial Alzheimer's disease. Biochemical studies revealed that PS1 exists predominantly as two processed fragments in cells and brain tissues. We prepared stably transfected cells expressing the wild-type and familia...
Topics
- Acetylcysteine
- Alzheimer Disease
- Amino Acid Sequence
- Brain Chemistry
- Coumarins
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Glycoproteins
- Humans
- Isocoumarins
- Kidney
- Membrane Proteins
- Molecular Sequence Data
- Multienzyme Complexes
- Mutation
- Neuroblastoma
- Peptide Fragments
- Precipitin Tests