Monoclonality and surface lesion-specific microsatellite alterations in premalignant and malignant neoplasia of uterine cervix: a local field effect of genomic instability and clonal evolution.

doi:10.1002/(sici)1098-2264(199902)24:2<127::aid-gcc5>3.0.co;2-8

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Article

Monoclonality and surface lesion-specific microsatellite alterations in premalignant and malignant neoplasia of uterine cervix: a local field effect of genomic instability and clonal evolution.

Genes, chromosomes & cancer - 1 Feb 1999

Chu T Y, Shen C Y, Lee H S, Liu H S

Abstract excerpt

Invasive squamous carcinoma of the uterine cervix (CC) arises from sequential progression of low-grade (L) and high-grade (H) squamous intraepithelial lesions (SILs). In clinical observations, these lesions are frequently found as synchronous multiple foci. The nature and evolutionary mechanism o...

Topics

Carcinoma in Situ
Carcinoma, Squamous Cell
Chromosome Mapping
Chromosomes, Human, Pair 3
Clone Cells
DNA, Neoplasm
DNA, Viral
Female
Genetic Markers
Genotype
Humans
Loss of Heterozygosity
Microsatellite Repeats
Neoplasm Invasiveness
Papillomaviridae

Source

Open in PubMed

Identifiers

PMID: 9885979
DOI: 10.1002/(sici)1098-2264(199902)24:2<127::aid-gcc5>3.0.co;2-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9885979-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Trinucleotide Repeat Expansion