A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection.

doi:10.1016/s0731-7085(98)00084-3

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Article

A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection.

Journal of pharmaceutical and biomedical analysis - 1 Sept 1998

Di Girolamo A, O'Neill W M, Wainer I W

Abstract excerpt

Paracetamol is a safe drug which has been used as an in-vivo probe to determine phase II metabolism in a HIV+/AIDS population. Due to the biohazard nature of HIV-infected samples, a high performance liquid chromatography (HPLC) assay which offers minimal sample manipulation and maximal specificit...

Topics

Acetaminophen
Acetonitriles
Acquired Immunodeficiency Syndrome
Chromatography, High Pressure Liquid
Glucuronates
HIV Seropositivity
Humans
Hydrogen-Ion Concentration
Phenotype
Reproducibility of Results
Sensitivity and Specificity
Sodium Acetate
Sulfates
Trifluoroacetic Acid
Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 9884209
DOI: 10.1016/s0731-7085(98)00084-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9884209-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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