Article
The bovine herpesvirus-1 LR ORF2 is critical for this gene's ability to restore the high wild-type reactivation phenotype to a herpes simplex virus-1 LAT null mutant.
The Journal of general virology - 1 Nov 2003
Mott Kevin R, Osorio Nelson, Jin Ling, Brick David J, Naito Julie, Cooper Jennifer, Henderson Gail, Inman Melissa, Jones Clinton, Wechsler Steven L, Perng Guey-Chuen
Abstract excerpt
During neuronal latency of herpes simplex virus (HSV)-1, the latency-associated transcript (LAT) is the only viral gene readily detectable. LAT is required for the high-level reactivation phenotype in animal models. LAT's anti-apoptotic activity was recently demonstrated by our group and it was proposed that LAT's anti-apoptotic function is involved in enhancing the reactivation phenotype. Recently, using...
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