Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation.

doi:10.1038/sj.onc.1202216

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Article

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation.

Oncogene - 3 Dec 1998

Wang X, Ohnishi K, Takahashi A, Ohnishi T

Abstract excerpt

p53 and poly(ADP-ribose) polymerase (PARP) are both DNA damage recognition proteins and can be functionally activated by DNA strand breaks. To understand the functional interaction between these two proteins, the effects of a PARP inhibitor, 3-aminobenzamide (3AB), on the p53 pathway were investi...

Topics

Benzamides
Blotting, Northern
Blotting, Western
Cell Survival
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA
DNA Damage
Gamma Rays
Gene Expression Regulation, Neoplastic
Glioblastoma
Humans
Mutation
Nuclear Proteins
Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases
Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 9879988
DOI: 10.1038/sj.onc.1202216

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9879988-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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