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Article

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation.

Oncogene - 3 Dec 1998

Wang X, Ohnishi K, Takahashi A, Ohnishi T

Abstract excerpt

p53 and poly(ADP-ribose) polymerase (PARP) are both DNA damage recognition proteins and can be functionally activated by DNA strand breaks. To understand the functional interaction between these two proteins, the effects of a PARP inhibitor, 3-aminobenzamide (3AB), on the p53 pathway were investigated in human glioblastoma cells with different p53 status. Consistent with previous studies, irradiation with...

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Identifiers

PMID: 9879988
DOI: 10.1038/sj.onc.1202216

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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