Article
Mapping of HIV-1 determinants of apoptosis in infected T cells.
Virology - 20 Dec 1998
Rapaport E, Casella C R, Ikl, Mustafa F, Isaak D, Finkel T H
Abstract excerpt
HIV-1 infection leads to death of CD4(+) T cells in vivo and in vitro, although the mechanisms of this cell death are not well defined. We used flow cytometry to concurrently analyze infection and apoptosis of the CD4(+) CEM T cell line and human peripheral blood mononuclear cells (PBMC). Surpris...
Topics
- Animals
- Apoptosis
- Cell Line
- Flow Cytometry
- Genes, nef
- Genes, vpr
- Genes, vpu
- HIV Core Protein p24
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Mice
- Mutation
- T-Lymphocytes