Article
Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals.
Blood - 1 Dec 1993
Oyaizu N, McCloskey T W, Coronesi M, Chirmule N, Kalyanaraman V S, Pahwa S
Abstract excerpt
This study investigates apoptosis as a mechanism for CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1) infection. Although several recent studies have shown that T cells of HIV-infected individuals show enhanced susceptibility to cell death by apoptosis, the mechanisms responsi...
Topics
- Acquired Immunodeficiency Syndrome
- Apoptosis
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Phenotype
- Receptors, Antigen, T-Cell