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Article

HIV-1 Env Glycoprotein Phenotype along with Immune Activation Determines CD4 T Cell Loss in HIV Patients.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2016

Joshi Anjali, Sedano Melina, Beauchamp Bethany, Punke Erin B, Mulla Zuber D, Meza Armando, Alozie Ogechika K, Mukherjee Debabrata, Garg Himanshu

Abstract excerpt

The mechanism behind the selective depletion of CD4(+) cells in HIV infections remains undetermined. Although HIV selectively infects CD4(+) cells, the relatively few infected cells in vivo cannot account for the extent of CD4(+) T cell depletion, suggesting indirect or bystander mechanisms. The role of virus replication, Env glycoprotein phenotype, and immune activation (IA) in this bystander phenomenon remains...

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Source

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Identifiers

PMID: 26764036
DOI: 10.4049/jimmunol.1501588
PMCID: PMC4744550

Genes

AIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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