Selective hippocampal lesions differentially affect the phenotypic fate of transplanted neuronal precursor cells.

doi:10.1006/exnr.1996.0081

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Article

Selective hippocampal lesions differentially affect the phenotypic fate of transplanted neuronal precursor cells.

Experimental neurology - 1 May 1996

Shihabuddin L S, Holets V R, Whittemore S R

Abstract excerpt

RN33B cells, a CNS-derived neuronal precursor cell line, transplanted into normal adult rat hippocampus can survive and morphologically differentiate with their ultimate morphology dependent on the integration site. This study examined the differentiation and structural integration of RN33B cells transplanted into the lesioned adult hippocampus. Pyramidal neurons of the CA1-3 regions or granular neurons in the...

Topics

Animals
Antigens, Polyomavirus Transforming
Cell Differentiation
Cell Line, Transformed
Colchicine
Excitatory Amino Acid Agonists
Female
Hippocampus
Kainic Acid
Mutation
Neuroglia
Neurons
Phenotype
Raphe Nuclei
Rats
Rats, Inbred Lew
Stem Cell Transplantation
Temperature

Source

Open in PubMed

Identifiers

PMID: 8635569
DOI: 10.1006/exnr.1996.0081

Genes

GFAP

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