Article
IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2001
Wolf J S, Chen Z, Dong G, Sunwoo J B, Bancroft C C, Capo D E, Yeh N T, Mukaida N, Van Waes C
Abstract excerpt
Interleukin 1alpha (IL-1alpha) is an important regulatory cytokine, the release of which after an injury can induce activation of transcription factors nuclear factor (NF)kappaB and activator protein (AP-1), which promote expression of genes involved in cell survival, proliferation, and angiogenesis. IL-1alpha is expressed autonomously by head and neck squamous cell carcinomas (HNSCCs) and a variety of other...
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