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Article

Positive feedback regulation of type I <i>IFN</i> genes by the IFN‐inducible transcription factor IRF‐7

11 Dec 1998

Abstract excerpt

The interferon regulatory factor (IRF) family of transcription factors regulate the interferon (IFN) system, among which IRF-3 is involved in the virus-induced IFN-beta gene expression. Here we show that another member IRF-7 is critical for the IFN-alpha gene induction. Unlike the IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription factor, and IRF-7 undergoes virus-induced...

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Identifiers

PMID: 9877175
DOI: 10.1016/s0014-5793(98)01514-2

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