Article
Tissue-specific positive feedback requirements for production of type I interferon following virus infection.
The Journal of biological chemistry - 13 May 2005
Prakash Arun, Smith Eric, Lee Chien-Kuo, Levy David E
Abstract excerpt
Type I interferon (IFN) is synthesized by most nucleated cells following viral infection. Robust IFN production in cell culture requires positive feedback expression of inducible signaling components, such as the transcription factor IRF7. However, the role of positive feedback and IRF7 in vivo may be more complex. We found that IFN produced locally in the respiratory tract of influenza virus-infected mice...
Topics
- Animals
- Cell Differentiation
- Cells, Cultured
- DNA-Binding Proteins
- Dendritic Cells
- Feedback, Physiological
- Fibroblasts
- Flow Cytometry
- Hematopoietic Stem Cells
- Immunoprecipitation
- Interferon Regulatory Factor-7
- Interferon Type I
- Interferon-alpha