Article
GnT-V expression and metastatic phenotypes in macrophage-melanoma fusion hybrids is down-regulated by 5-Aza-dC: evidence for methylation sensitive, extragenic regulation of GnT-V transcription.
Gene - 7 Jun 2006
Chakraborty Ashok K, Sousa Josane de Frietas, Chakraborty Debjit, Funasaka Yoko, Bhattacharya Mahasweta, Chatterjee Amitava, Pawelek John
Abstract excerpt
Beta1,6-acetylglucosaminyltransferase V (GnT-V) forms beta1,6 branching on the trimannosyl terminus of N-glycans, allowing for the production of beta1,6Glc-NAc-bearing oligosaccharides. These are used by healthy myeloid cells and cancer cells alike for systemic migration. GnT-V has multiple glycoprotein substrates and thereby exerts global effects on cancer progression, characteristic of a master regulator of...
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