Article
Melanoma Cells Can Adopt the Phenotype of Stromal Fibroblasts and Macrophages by Spontaneous Cell Fusion in Vitro.
International journal of molecular sciences - 2 Jun 2016
Kemény Lajos V, Kurgyis Zsuzsanna, Buknicz Tünde, Groma Gergely, Jakab Ádám, Zänker Kurt, Dittmar Thomas, Kemény Lajos, Németh István B
Abstract excerpt
After the removal of primary cutaneous melanoma some patients develop local recurrences, even after having histologically tumor-free re-excision. A potential explanation behind this phenomenon is that tumor cells switch their phenotype, making their recognition via standard histopathological assessments extremely difficult. Tumor-stromal cell fusion has been proposed as a potential mechanism for tumor cells to...
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