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Article

Development of melanocyte progenitors in murine Steel mutant neural crest explants cultured with stem cell factor, endothelin-3, or TPA.

Pigment cell research - 1 Oct 1998

Ono H, Kawa Y, Asano M, Ito M, Takano A, Kubota Y, Matsumoto J, Mizoguchi M

Abstract excerpt

Stem cell factor (SCF) has been suggested to be indispensable for the development of neural crest cells into melanocytes because Steel mutant mice (i.e., Sl/Sl(d)) have no pigmented hairs. On the other hand, it has been demonstrated that the addition of endothelin 3 (ET-3) or TPA to neural crest cell cultures can induce melanocyte differentiation without addition of extrinsic SCF. In this study, we excluded the...

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PMID: 9877100
DOI: 10.1111/j.1600-0749.1998.tb00738.x

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