Article
A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding.
Protein science : a publication of the Protein Society - 1 Jan 2015
Longo Liam M, Tenorio Connie A, Kumru Ozan S, Middaugh C Russell, Blaber Michael
Abstract excerpt
The halophile environment has a number of compelling aspects with regard to the origin of structured polypeptides (i.e., proteogenesis) and, instead of a curious niche that living systems adapted into, the halophile environment is emerging as a candidate "cradle" for proteogenesis. In this viewpoint, a subsequent halophile-to-mesophile transition was a key step in early evolution. Several lines of evidence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.