Article
Gastrin-regulated expression of p53 in transformed enterochromaffin-like cells in the African rodent mastomys.
Journal of clinical gastroenterology - 1 Jan 1998
Luque E A, Tang L H, Bortecen K H, Kidd M, Miu K, Efstathiou J A, Modlin I M
Abstract excerpt
The tumor suppressor p53 functions at the G1/S-phase checkpoint of the cell cycle to direct cells that have accumulated somatic mutations toward apoptosis and away from mitosis. The p53 gene is commonly mutated in human cancers, but the molecular mechanisms regulating this event are not clear. Th...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Southern
- Blotting, Western
- Cell Transformation, Neoplastic
- DNA Primers
- DNA, Neoplasm
- Enterochromaffin-like Cells
- Gastrins
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Histamine H2 Antagonists
- Immunohistochemistry
- Molecular Sequence Data