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Article

Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1994

Li B, Greenberg N, Stephens L C, Meyn R, Medina D, Rosen J M

Abstract excerpt

Regulatory sequences derived from the rat whey acidic protein gene have been used to preferentially overexpress a murine 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice. Several different lines of mice expressing the 172Arg-->Leu mutant p53 displayed an impaired ability to lactate, and the mice expressing the highest levels of mutant p53 were unable to nurse their young. This failure was related...

Topics

Animals
Apoptosis
Base Sequence
Codon
Cytoplasm
Female
Gamma Rays
Gene Expression Regulation
Lactation Disorders
Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Milk Proteins

Molecular Sequence Data

Mutation

Organ Specificity

Pregnancy

Rats

Source

Identifiers

PMID: 7947386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7947386-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development.PMID 7947386Read ↗

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