Article
Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene.
Annals of surgery - 1 Jun 1994
Evers B M, Rady P L, Sandoval K, Arany I, Tyring S K, Sanchez R L, Nealon W H, Townsend C M, Thompson J C
Abstract excerpt
OBJECTIVE: This study determined whether genomic amplification of HER-2/neu or mutations of the p53 and ras genes were present in gastrinomas. SUMMARY BACKGROUND DATA: Amplification of HER-2/neu, a proto-oncogene related to the epidermal growth factor receptor, and mutation of the ras proto-oncogene and p53 tumor suppressor gene appear to play a role in the pathogenesis of some human cancers. Little is known...
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