Article
Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene.
Annals of surgery - 1 Jun 1994
Evers B M, Rady P L, Sandoval K, Arany I, Tyring S K, Sanchez R L, Nealon W H, Townsend C M, Thompson J C
Abstract excerpt
OBJECTIVE: This study determined whether genomic amplification of HER-2/neu or mutations of the p53 and ras genes were present in gastrinomas. SUMMARY BACKGROUND DATA: Amplification of HER-2/neu, a proto-oncogene related to the epidermal growth factor receptor, and mutation of the ras proto-oncog...
Topics
- Base Sequence
- Female
- Gastrinoma
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genes, ras
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Oncogene Proteins, Viral
- Proto-Oncogene Mas
- Receptor, ErbB-2
- Tumor Cells, Cultured