Article
Protein adduction causes non-mutational inhibition of p53 tumor suppressor.
Cell reports - 31 Jan 2023
Caspa Gokulan Ravindran, Paulrasu Kodisundaram, Azfar Jamal, El-Rifai Wael, Que Jianwen, Boutaud Olivier G, Ban Yuguang, Gao Zhen, Buitrago Monica Garcia, Dikalov Sergey I, Zaika Alexander I
Abstract excerpt
p53 is a key tumor suppressor that is frequently mutated in human tumors. In this study, we investigated how p53 is regulated in precancerous lesions prior to mutations in the p53 gene. Analyzing esophageal cells in conditions of genotoxic stress that promotes development of esophageal adenocarcinoma, we find that p53 protein is adducted with reactive isolevuglandins (isoLGs), products of lipid peroxidation....
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