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Article

Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis.

Molecular cancer research : MCR - 1 Feb 2010

Zuo Jianhong, Ishikawa Tohru, Boutros Shadi, Xiao Zhiqiang, Humtsoe Joseph O, Kramer Randall H

Abstract excerpt

Evidence shows that Bcl-2 family members play a direct role in the development of some human malignancies. However, the mechanism by which Bcl-2 may influence tumor cell invasion and metastasis remains unclear. Ectopic overexpression of Bcl-2 in the human squamous carcinoma cell line HSC-3 enhanced tumorigenicity and experimental pulmonary metastasis. Interestingly, Bcl-2-expressing cells showed morphologic...

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PMID: 20145039
DOI: 10.1158/1541-7786.MCR-09-0354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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