Article
Fibronectin gene polymorphisms associated with fibrosing alveolitis in systemic sclerosis.
American journal of respiratory cell and molecular biology - 1 Jan 1999
Avila J J, Lympany P A, Pantelidis P, Welsh K I, Black C M, du Bois R M
Abstract excerpt
Systemic sclerosis (SSc), a multisystem immunologic disease of unknown etiology, is commonly manifested in the lung as fibrosing alveolitis (FASSc). There is evidence to support the role of genetic factors in the predisposition to pulmonary fibrosis in SSc (HLA DR3/DR52a). This association is not...
Topics
- Adult
- Aged
- Deoxyribonuclease HindIII
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Female
- Fibronectins
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Pulmonary Fibrosis
- Scleroderma, Systemic