Does the polymorphism 677C-T of the 5,10-methylenetetrahydrofolate reductase gene contribute to homocysteine-related vascular disease?

doi:10.1023/a:1005414617390

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Article

Does the polymorphism 677C-T of the 5,10-methylenetetrahydrofolate reductase gene contribute to homocysteine-related vascular disease?

Journal of inherited metabolic disease - 1 Dec 1998

Thuillier L, Chadefaux-Vekemans B, Bonnefont J P, Kara A, Aupetit J, Rochette C, Montalescot G, Couty M C, Kamoun P, Ankri A

Abstract excerpt

Whether the 677C-T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene acts as a risk factor for homocysteine-related vascular disease remains a matter of debate. Testing for the 677C-T nucleotide substitution and assay of plasma homocysteine were carried out simultaneously in 6...

Topics

5,10-Methylenetetrahydrofolate Reductase (FADH2)
Adolescent
Adult
Aged
Aged, 80 and over
Erythrocytes
Female
Folic Acid
Genotype
Homocysteine
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Oxidoreductases

Source

Open in PubMed

Identifiers

PMID: 9870206
DOI: 10.1023/a:1005414617390

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9870206-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Risk Factors

Vascular Diseases