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Article

An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes.

The American journal of physiology - 1 May 1999

Kim S J, Iizuka K, Kelly R A, Geng Y J, Bishop S P, Yang G, Kudej A, McConnell B K, Seidman C E, Seidman J G, Vatner S F

Abstract excerpt

Left Ventricular (LV) myocytes were isolated from 15-wk-old male mice bearing the Arg403 --> Gln alpha-cardiac myosin heavy chain missense mutation (alpha-MHC403/+), a model of familial hypertrophic cardiomyopathy. LV myocytes were classified morphologically: type I, rod shaped with parallel myofibrils; type II, irregularly shaped, shorter and wider than wild-type (WT) control cells, with parallel myofibrils; and...

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Identifiers

PMID: 10330263
DOI: 10.1152/ajpheart.1999.276.5.H1780

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