Article
Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q-->R genetic polymorphism.
Journal of lipid research - 1 Jan 1999
Cao H, Girard-Globa A, Berthezene F, Moulin P
Abstract excerpt
High density lipoprotein (HDL)-associated paraoxonase (PON) seems to play a major role in the protection of low density lipoprotein (LDL) against peroxidation by HDL, and the partly purified enzyme exerts a dose-dependent protective effect. A common polymorphism of the human gene (192 Q-->R) modu...
Topics
- Aryldialkylphosphatase
- Carboxylic Ester Hydrolases
- Copper
- Diabetes Mellitus, Type 2
- Esterases
- Female
- Genotype
- Humans
- In Vitro Techniques
- Lipid Peroxidation
- Lipoproteins, HDL
- Lipoproteins, LDL
- Male
- Middle Aged
- Paraoxon
- Polymorphism, Genetic