Article
The effect of HDL-bound and free PON1 on copper-induced LDL oxidation.
Chemico-biological interactions - 25 Sept 2016
Bayrak Ahmet, Bayrak Tülin, Bodur Ebru, Kılınç Kamer, Demirpençe Ediz
Abstract excerpt
Oxidative modification of LDL plays an important role in the development of atherosclerosis. High-density lipoprotein (HDL) confers protection against atherosclerosis and the antioxidative properties of paraoxonase 1 (PON1) has been suggested to contribute to this effect of HDL. The PON1 exist in two major polymorphic forms (Q and R), which regulate the concentration and activity of the enzyme and alter its...
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