Article
c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets.
Genes & development - 15 Dec 1998
Bush A, Mateyak M, Dugan K, Obaya A, Adachi S, Sedivy J, Cole M
Abstract excerpt
We report here that the expression of virtually all proposed c-Myc target genes is unchanged in cells containing a homozygous null deletion of c-myc. Two noteworthy exceptions are the gene cad, which has reduced log phase expression and serum induction in c-myc null cells, and the growth arrest g...
Topics
- Animals
- Aspartate Carbamoyltransferase
- Blotting, Northern
- Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
- Cell Cycle
- Cell Division
- Cell Line
- Dihydroorotase
- Down-Regulation
- Eukaryotic Initiation Factor-4E
- Gene Deletion
- Gene Expression Regulation
- Genes, myc
- Genes, p53
- Homozygote