An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants.

doi:10.1128/MCB.15.5.2527

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants.

Molecular and cellular biology - 1 May 1995

Miltenberger R J, Sukow K A, Farnham P J

Abstract excerpt

To better understand the signaling pathways which lead to DNA synthesis in mammalian cells, we have studied the transcriptional activation of genes needed during the S phase of the cell cycle. Transcription of the gene encoding a pyrimidine biosynthetic enzyme, carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase (cad), increases at the G1/S-phase boundary. We have...

Topics

3T3 Cells
Animals
Aspartate Carbamoyltransferase
Base Sequence
Binding Sites
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
Cricetinae
DNA
Dihydroorotase
G1 Phase
Genes, myc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesocricetus

Mice

Molecular Sequence Data

Multienzyme Complexes

Mutation

Promoter Regions, Genetic

S Phase

Source

Open in PubMed Open full text

Identifiers

PMID: 7739536
DOI: 10.1128/MCB.15.5.2527
PMCID: PMC230483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7739536-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants.PMID 7739536Read ↗

c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets.Semantic proximity Read ↗

Cyclin-dependent kinase activation and S-phase induction of the cyclin B1 gene are linked through the CCAAT elements.Semantic proximity Read ↗

Relationship between E1A binding to cellular proteins, c-myc activation and S-phase induction.Semantic proximity Read ↗

Cell-cycle regulatory sequences in a hamster histone promoter and their interactions with cellular factors.Semantic proximity Read ↗

The G1/S boundary-specific enhancer of the rat cdc2 promoter.Semantic proximity Read ↗

Growth state-dependent binding of USF-1 to a proximal promoter E box element in the rat plasminogen activator inhibitor type 1 gene.Semantic proximity Read ↗

Identification of a 10-base pair protein binding site in the promoter of the hamster H3.2 gene required for the S phase dependent increase in transcription and its interaction with a Jun-like nuclear factor.Semantic proximity Read ↗

T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.