Article
Investigation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone for in vivo and iIn vitro murine embryopathy and embryonic ras mutations.
The Journal of pharmacology and experimental therapeutics - 1 Dec 1998
Winn L M, Kim P M, Wells P G
Abstract excerpt
The teratological potential of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is unknown. In vivo, NNK (100 mg/kg i.p.) was administered to pregnant CD-1 mice during organogenesis, with or without pretreatment with the P450 inducer phenobarbital (60 mg/kg i.p.). With NNK alon...
Topics
- Abnormalities, Drug-Induced
- Animals
- Carcinogens
- Embryo, Mammalian
- Female
- Fetus
- Genes, ras
- Mice
- Mutation
- Nitrosamines
- Organ Culture Techniques
- Phenobarbital
- Plants, Toxic
- Pregnancy
- Nicotiana