HLA-B35 frequency variations correlate with malaria infection in Sardinia.

doi:10.1111/j.1399-0039.1998.tb03072.x

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Article

HLA-B35 frequency variations correlate with malaria infection in Sardinia.

Tissue antigens - 1 Nov 1998

Contu L, Carcassi C, Orrù S, Mulargia M, Arras M, Boero R, Gessa S, Loizedda A L, Lai S, Floris L

Abstract excerpt

The hypothesis of a possible selective role of malaria in HLA allele frequency variations was investigated in Sardinia by typing completely 1,039 individuals for HLA: 536 from six lowland villages exposed to malaria until 1948, and 503 from six highland villages with no history of malaria. Anothe...

Topics

Alleles
Altitude
Gene Frequency
Genetic Variation
Globins
HLA-B Antigens
HLA-B35 Antigen
Humans
Italy
Malaria, Falciparum
Mathematical Computing
Microsatellite Repeats
Mutation
beta-Thalassemia

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