Article
HLA-B35 frequency variations correlate with malaria infection in Sardinia.
Tissue antigens - 1 Nov 1998
Contu L, Carcassi C, Orrù S, Mulargia M, Arras M, Boero R, Gessa S, Loizedda A L, Lai S, Floris L
Abstract excerpt
The hypothesis of a possible selective role of malaria in HLA allele frequency variations was investigated in Sardinia by typing completely 1,039 individuals for HLA: 536 from six lowland villages exposed to malaria until 1948, and 503 from six highland villages with no history of malaria. Another 1,928 individuals from 136 villages scattered all over the island were studied to establish if the HLA allele...
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