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Article

Evidence for malaria selection of a CR1 haplotype in Sardinia.

Genes and immunity - 1 Oct 2011

Kosoy R, Ransom M, Chen H, Marconi M, Macciardi F, Glorioso N, Gregersen P K, Cusi D, Seldin M F

Abstract excerpt

Complement receptor 1 (CR1) levels have been associated with malarial susceptibility and/or severity of the disease in different population groups, and CR1 is a receptor for Plasmodium falciparum. In this study, multiple CR1 single-nucleotide polymorphisms (SNPs) showed strong evidence of population differentiation between Sardinian and other European ethnic groups. Cross population algorithms comparing haplotype...

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Identifiers

PMID: 21593778
DOI: 10.1038/gene.2011.33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for malaria selection of a CR1 haplotype in Sardinia.PMID 21593778Read ↗

Population-specific positive selection on low CR1 expression in malaria-endemic regionsSemantic proximity Read ↗

The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populationsSemantic proximity Read ↗

CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity.Semantic proximity Read ↗

A complement receptor-1 polymorphism with high frequency in malaria endemic regions of Asia but not Africa.Semantic proximity Read ↗

High CR1 level and related polymorphic variants are associated with cerebral malaria in eastern-India.Semantic proximity Read ↗

Genome-wide scan with nearly 700,000 SNPs in two Sardinian sub-populations suggests some regions as candidate targets for positive selection.Semantic proximity Read ↗

Sardinians genetic background explained by runs of homozygosity and genomic regions under positive selection.Semantic proximity Read ↗

The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases.Semantic proximity Read ↗

Geographical distribution of complement receptor type 1 variants and their associated disease risk.Semantic proximity Read ↗

Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes.Semantic proximity Read ↗

Role of CR1 Knops polymorphism in the pathophysiology of malaria: Indian scenario.Semantic proximity Read ↗

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