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Article

Characterization of the nuclear localization signal in the avian sarcoma virus integrase.

Gene - 26 Nov 1998

Kukolj G, Katz R A, Skalka A M

Abstract excerpt

A sequence of 21 amino acids (aa) in the C-terminal region of the 286-aa avian sarcoma virus (ASV) integrase (IN) protein has been shown previously to mediate nuclear localization of both IN and beta-galactosidase (betaGal) protein fused to it. This karyophilic sequence includes a high proportion of prolines and residues with basic side chains. In this report, site-directed mutagenesis was used to introduce...

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Identifiers

PMID: 9858717
DOI: 10.1016/s0378-1119(98)00169-3

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