Article
Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.
International journal of molecular medicine - 1 Nov 1998
Voncken J W, Baram T Z, Gonzales-Gomez I, Van Schaick H, Shih J C, Chen K, Groffen J, Heisterkamp N
Abstract excerpt
The in vivo function of proteins which regulate activity of the GTPase Rac is largely unknown. Here we establish that mice lacking bcr, a known GTPase activating protein for Rac, exhibit a defect in the regulation of both hormonal and behavioral stress responses. Bcr null mutants demonstrate prol...
Topics
- Aggression
- Animals
- Behavior, Animal
- Biogenic Amines
- Blood Glucose
- Brain Chemistry
- Cold Temperature
- Glucocorticoids
- Humans
- Lactic Acid
- Liver
- Male
- Mice
- Mice, Knockout
- Phenotype
- Stress, Psychological
- Swimming