Article
Merlin, the neurofibromatosis type 2 gene product, and ?1 integrin associate in isolated and differentiating Schwann cells
1 Dec 1998
Abstract excerpt
Neurofibromatosis type 2, a disease characterized by the formation of multiple nervous system tumors, especially schwannomas, is caused by mutation in the gene-encoding merlin/schwannomin. The molecular mechanism by which merlin functions as a tumor suppressor is unknown, but is hypothesized to involve plasma membrane and cytoskeleton interaction. Several merlin antibodies were used to study merlin expression,...
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