Article
Modulation of wingless signaling by Notch in Drosophila.
Mechanisms of development - 1 Sept 1994
Hing H K, Sun X, Artavanis-Tsakonas S
Abstract excerpt
Extensive genetic and molecular analyses indicate that Notch acts as a transmembrane receptor in an evolutionarily conserved cell interaction mechanism that appears to control a common step in the progression of an uncommitted cell towards the differentiated state. In Drosophila, Notch mutations were shown to affect the development of a broad spectrum of tissues, including the wing. We found that mutations in the...
Topics
- Animals
- Cell Differentiation
- Drosophila
- Genetic Linkage
- Mutation
- Signal Transduction
- Wings, Animal