Self-immolative nitrogen mustard prodrugs for suicide gene therapy.

doi:10.1021/jm980425k

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Article

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.

Journal of medicinal chemistry - 17 Dec 1998

Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer C J

Abstract excerpt

Four new potential self-immolative prodrugs derived from phenol and aniline nitrogen mustards, four model compounds derived from their corresponding fluoroethyl analogues and two new self-immolative linkers were designed and synthesized for use in the suicide gene therapy termed GDEPT (gene-direc...

Topics

Animals
Antineoplastic Agents, Alkylating
Colorectal Neoplasms
Drug Screening Assays, Antitumor
Genetic Therapy
Inhibitory Concentration 50
Mechlorethamine
Mice
Mutation
Prodrugs
Transfection
Tumor Cells, Cultured
gamma-Glutamyl Hydrolase

Source

Open in PubMed

Identifiers

PMID: 9857097
DOI: 10.1021/jm980425k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9857097-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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