Article
Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans.
PLoS genetics - 1 Jan 2012
Bendesky Andres, Pitts Jason, Rockman Matthew V, Chen William C, Tan Man-Wah, Kruglyak Leonid, Bargmann Cornelia I
Abstract excerpt
Aggregation is a social behavior that varies between and within species, providing a model to study the genetic basis of behavioral diversity. In the nematode Caenorhabditis elegans, aggregation is regulated by environmental context and by two neuromodulatory pathways, one dependent on the neuropeptide receptor NPR-1 and one dependent on the TGF-β family protein DAF-7. To gain further insight into the genetic...
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