Article
Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease.
Neurology - 1 Dec 1998
Parsian A, Racette B, Zhang Z H, Chakraverty S, Rundle M, Goate A, Perlmutter J S
Abstract excerpt
A mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the alpha-synuclein gene. None of the familial cases of PD carried a mutation within the alpha-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the alpha-synuclein...
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