[Apolipoprotein E and its alleles in healthy subjects and in atherosclerosis].

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Article

[Apolipoprotein E and its alleles in healthy subjects and in atherosclerosis].

Annales de biologie clinique - 1 Jan 2000

Couderc R, Bailleul S

Abstract excerpt

Apolipoprotein E (apo E) plays a central role in lipoprotein metabolism as a ligand for LDL-, VLDL- and remnant receptors. It is mainly synthesized by hepatocytes and also by monocytes-macrophages. There are three common codominant isoforms E2, E3 and E4. Apo E2 binds defectively to LDL- and to remnant-receptors. Apo E alleles frequency varies from population to population around the world. In Europe, E4 allele...

Topics

Alleles
Animals
Apolipoproteins E
Arteriosclerosis
Cardiovascular Diseases
Gene Frequency
Humans
Hyperlipoproteinemia Type III
Ligands
Liver
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 9853024

Provenance

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