Article
Apolipoprotein E polymorphism and atherosclerosis.
Arteriosclerosis (Dallas, Tex.) - 1 Jan 2000
Davignon J, Gregg R E, Sing C F
Abstract excerpt
The apo E locus contributes to determining the variation in plasma cholesterol levels of healthy and diseased populations. It also influences the expression of hyperlipidemia and appears to modulate the susceptibility to atherosclerosis in a complex multifactorial interaction. There is evidence that the presence of apo E2 is protective, whereas that of apo E4 predisposes to coronary artery disease. The burden of...
Topics
- Alleles
- Apolipoproteins
- Apolipoproteins E
- Arteriosclerosis
- Coronary Disease
- Humans
- Lipids
- Lipoproteins
- Phenotype
- Polymorphism, Genetic
- Radiography
- Risk Factors