Article
Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Dec 1998
Morrill J A, Brown R H, Cannon S C
Abstract excerpt
The skeletal muscle L-type Ca channel serves a dual role as a calcium-conducting pore and as the voltage sensor coupling t-tubule depolarization to calcium release from the sarcoplasmic reticulum. Mutations in this channel cause hypokalemic periodic paralysis (HypoPP), a human autosomal dominant...
Topics
- Biological Transport
- Calcium
- Calcium Channels
- Calcium Channels, L-Type
- Cells, Cultured
- Humans
- Ion Channel Gating
- Kinetics
- Muscle Proteins
- Muscle, Skeletal
- Mutation
- Paralyses, Familial Periodic
- Time Factors