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Article

The gene tinman is required for specification of the heart and visceral muscles in Drosophila.

Development (Cambridge, England) - 1 Jul 1993

Bodmer R

Abstract excerpt

The homeobox-containing gene tinman (msh-2, Bodmer et al., 1990 Development 110, 661-669) is expressed in the mesoderm primordium, and this expression requires the function of the mesoderm determinant twist. Later in development, as the first mesodermal subdivisions are occurring, expression becomes limited to the visceral mesoderm and the heart. Here, I show that the function of tinman is required for visceral...

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PMID: 7915669
DOI: 10.1242/dev.118.3.719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The gene tinman is required for specification of the heart and visceral muscles in Drosophila.PMID 7915669Read ↗

Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.Semantic proximity Read ↗

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.Semantic proximity Read ↗

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.Semantic proximity Read ↗

A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development.Semantic proximity Read ↗

tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman.Semantic proximity Read ↗

The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart.Semantic proximity Read ↗

Developmental paradigms in heart disease: insights from tinman.Semantic proximity Read ↗

Heart development in Drosophila requires the segment polarity gene wingless.Semantic proximity Read ↗

Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila.Semantic proximity Read ↗

Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis.Semantic proximity Read ↗

Tinman regulates the transcription of the beta3 tubulin gene (betaTub60D) in the dorsal vessel of Drosophila.Semantic proximity Read ↗

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila.Semantic proximity Read ↗

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