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Article

Heart development in Drosophila requires the segment polarity gene wingless.

Developmental biology - 1 Jun 1995

Wu X, Golden K, Bodmer R

Abstract excerpt

Mesoderm induction has been studied in many systems and some of the factors involved have been identified. Although the heart is mesodermal in origin, the molecular basis of heart development is essentially unknown. The Drosophila heart is a simple tubular structure similar to the early heart tube in vertebrates. The homeobox gene, tinman, has been shown to be crucial for heart formation in Drosophila. Several...

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Identifiers

PMID: 7781903
DOI: 10.1006/dbio.1995.1174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heart development in Drosophila requires the segment polarity gene wingless.PMID 7781903Read ↗

The wingless signaling pathway is directly involved in Drosophila heart development.Semantic proximity Read ↗

The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart.Semantic proximity Read ↗

Gata factor Pannier is required to establish competence for heart progenitor formation.Semantic proximity Read ↗

The gene tinman is required for specification of the heart and visceral muscles in Drosophila.Semantic proximity Read ↗

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.Semantic proximity Read ↗

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.Semantic proximity Read ↗

ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors.Semantic proximity Read ↗

The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision.Semantic proximity Read ↗

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The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.Semantic proximity Read ↗

Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis.Semantic proximity Read ↗

A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos.Semantic proximity Read ↗

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