Article
What do we learn from a few familial Alzheimer's disease cases?
Journal of neural transmission. Supplementum - 1 Jan 1998
Haass C, Baumeister R
Abstract excerpt
Alzheimer's disease is the most common form of dementia. About 90% of the cases occur sporadically whereas in 10% of the cases mutations were found within three different genes. Mutations in the gene encoding the beta-Amyloid precursor protein (beta APP) are located in the ultimate neighborhood o...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amino Acid Substitution
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Animals
- Aspartic Acid Endopeptidases
- Endopeptidases
- Genetic Predisposition to Disease
- Humans
- Membrane Proteins
- Molecular Sequence Data
- Point Mutation
- Presenilin-1
- Protein Structure, Secondary
