Article
A century of Alzheimer's disease.
Science (New York, N.Y.) - 3 Nov 2006
Goedert Michel, Spillantini Maria Grazia
Abstract excerpt
One hundred years ago a small group of psychiatrists described the abnormal protein deposits in the brain that define the most common neurodegenerative diseases. Over the past 25 years, it has become clear that the proteins forming the deposits are central to the disease process. Amyloid-beta and tau make up the plaques and tangles of Alzheimer's disease, where these normally soluble proteins assemble into...
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